张琳，理学博士，副教授，硕士生导师，骨干人才。2021年6月博士毕业于南开老员工命科学学院，2021年9月-2023年2月在天津医科大学担任讲师，2023年3月加入jbo竞博体育电竞，作为科创中心新型生物材料及疾病诊疗研发团队成员。现为中国生物材料学会会员，中国细胞生物学会会员，《离子交换与吸附》核心期刊青年编委。
研究方向为生物活性复合材料的制备与应用，通过工程化手段制备纳米颗粒、功能性水凝胶、复合纤维膜等多种材料，利用自调控方式从基因水平改变细胞活性，实现肿瘤靶向治疗，纤维化疾病治疗、骨组织修复、软组织再生等。
现主持国家自然科学基金青年项目一项、山东省自然科学基金青年项目一项，生物活性材料教育部重点实验室开放基金一项，jbo竞博体育电竞人才项目一项，参与国家重点研发计划、面上基金等项目，指导本科生参与老员工创新创业项目及口腔医学技术专业本科生毕业设计。累计发表论文20余篇，其中以第一作者或通讯作者发表论文7篇，申请国家发明专利3项。担任Chemical Engineering Journal、Carbohydrate Polymers、International Journal of Biological Macromolecules等期刊审稿人。
教授课程：本科生 口腔材料学；研究生 口腔生物材料学
科研项目：
1. 国家自然科学基金青年项目一项，2024.1-2026.12，30万，主持
2. 山东省自然科学基金青年项目一项，2023.1-2025.12，15万，主持
3. 生物活性材料教育部重点实验室开放基金一项，2023.8-2024.8，1.6万，主持
4. jbo竞博体育电竞人才项目一项，2023.3-2028.2，200万，主持
研究方向：
1.功能性复合材料的构建及其在组织修复领域的研究
2.多功能复合纳米材料的修饰及其靶向肿瘤治疗的研究
招生专业：医学技术、医用生物化学与分子生物学、生物医学工程（课题组长期招收有科研兴趣的员工，欢迎联系）
联系方式：linzhangstar@163.com
代表性成果：
一作或通讯
1. Xiangsheng Liu, Yufei Liu, Jie Zhou, Xinyi Yu, Jinpeng Wan, Jie Wang, Shaojin Lei, Zeyu Zhang, Lin Zhang*, Shufang Wang*, Porous Collagen Sponge Loaded with Large Efficacy-potentiated Exosome-Mimicking Nanovesicles for Diabetic Skin Wound Healing, ACS Biomaterials Science & Engineering, ACS Biomaterials Science & Engineering. 2024, 10, 975-986.
2. Lin Zhang, Yunsheng Dong, Yufei Liu, Xiangsheng Liu, Zhitao Wang, Jinpeng Wan, Xinyi Yu, Shufang Wang*，Multifunctional hydrogel/platelet-rich fibrin/nanofibers scaffolds with cell barrier and osteogenesis for guided tissue regeneration/guided bone regeneration applications. International Journal of Biological Macromolecules 2023, 253, 126960.
3. Lin Zhang#, Yifan Tai#, Xiangsheng Liu, Yufei Liu, Yunsheng Dong, Yujie Liu, Chao Yang, Deling Kong, Chunxiao Qi∗, Shufang Wang∗, Adam C. Midgley∗. Natural polymeric and peptide-loaded composite wound dressings for scar prevention. Applied Materials Today 2021, 25, 101186.
4. Lin Zhang, Hongyu Yan, Yifan Tai, Yueming Xue, Yongzhen Wei, Kai Wang, Qiang Zhao, Shufang Wang*, Deling Kong and Adam C. Midgley *. Design and Evaluation of a Polypeptide That Mimics the Integrin Binding Site for EDA Fibronectin to Block Profibrotic Cell Activity. International Journal of Molecular Sciences. 2021, 22, 1575.
5. Lin Zhang, Yunsheng Dong, Na Zhang, Jie Shi, Xiangyun Zhang, Chunxiao Qi, Adam C. Midgley, Shufang Wang*. Potentials of sandwich-like chitosan/polycaprolactone/gelatin scaffolds for guided tissue regeneration membrane. Materials Science & Engineering C 2020,109, 110618.
6. Lin Zhang, Yunsheng Dong, Yueming Xue, Jie Shi, Xiangyun Zhang, Yufei Liu, Adam C. Midgley, Shufang Wang*. Multifunctional Triple-Layered Composite Scaffolds Combining Platelet-Rich Fibrin Promote Bone Regeneration. ACS Biomaterials Science & Engineering 2019, 5, 6691.
7. Lin Zhang, Yina Ma, Xiaochen Pan, Siyuan Chen, Huahong Zhuang, Shufang Wang*. A composite hydrogel of chitosan/heparin/poly (γ-glutamic acid) loaded with superoxide dismutase for wound healing. Carbohydrate Polymers 2018, 180, 168.
参与论文
8. Yufei Liu, Zhiling Zhang*, Biao Wang, Yunsheng Dong, Congrui Zhao, Yanhong Zhao, Lin Zhang, Xiangsheng Liu, Jingyue Guo, Yuehua Chen, Jie Zhou, Tingting Yang, Yanying Wang, Hao Liu, Shufang Wang*, Inflammation-Stimulated MSC-Derived Small Extracellular Vesicle miR-27b-3p Regulates Macrophages by Targeting CSF-1 to Promote Temporomandibular Joint Condylar Regeneration, Small, 2022, 2107354.
9. Yunsheng Dong, Yufei Liu, Yuehua Chen, Xun Sun, Lin Zhang, Zhiling Zhang, Yanying Wang, Chunxiao Q , Shufang Wang, Qiang Yang*, Spatiotemporal regulation of endogenous MSCs using a functional injectable hydrogel system for cartilage regeneration, NPG Asia Materials 2021, 13(1), 71.
10. Yueming Xue, Chunxiao Qi, Yunsheng Dong, Lin Zhang, Xiangsheng Liu, Yufei Liu, Shufang Wang*. Poly (γ-glutamic acid)/chitooligo-saccharide/papain hydrogel prevents hypertrophic scar during skin wound healing. Journal of Biomedical Materials Research: Part B - Applied Biomaterials. 2021, 1–11
11. Yunsheng Dong, Xun Sun, Zhiling Zhang, Yufei Liu, Lin Zhang, Xiangyun Zhang, Ying Huang, Yanhong Zhao, Chunxiao Qi, Adam C. Midgley, Shufang Wang*, Qiang Yang*. Regional and sustained dual-release of growth factors from biomimetic tri-layered scaffolds for the repair of large-scale osteochondral defects. Applied Materials Today. 2020, 19, 100548-100561.
12. Yunsheng Dong, Huahong Zhuang, Yan Hao, Lin Zhang, Qiang yang*, Yufei Liu, Chunxiao Qi, Shufang Wang*. Poly(N-isopropyl-acrylamide)/poly(γ-glutamic acid) thermo-sensitive hydrogels loaded with superoxide dismutase for wound dressing application. International Journal of Nanomedicine. 2020, 15, 1939–1950.
13. Jie Shi, Xiangyun Zhang, Li Jiang, Lin Zhang, Yunsheng Dong, Adam C. Midgley, Deling Kong, Shufang Wang*. Regulation of the inflammatory response by vascular grafts modified with Aspirin-Triggered Resolvin D1 promotes blood vessel regeneration. Acta Biomaterialia. 2019, 97, 360–373.
14. Jie Shi, Siyuan Chen, Lina Wang, Xiangyun Zhang, Jingchen Gao, Li Jiang, Di Tang, Lin Zhang, Adam Midgley, Deling Kong, Shufang Wang*. Rapid endothelialization and controlled smooth muscle regeneration by electrospun heparin-loaded polycaprolactone/gelatin vascular grafts. Journal of Biomedical Materials Research: Part B - Applied Biomaterials. 2019, 107(6): 2040–2049.
15. Xiangyun Zhang, Jie Shi, Siyuan Chen, Yunsheng Dong, Lin Zhang, Adam C. Midgley, Deling Kong, Shufang Wang* Polycaprolactone/gelatin degradable vascular grafts simulating endothelium functions modified by nitric oxide generation. Regenerative Medicine 2019, 14(12), 1089-1105.
发明专利
1. 王淑芳，张琳，张娜，董云生. 中国发明专利，一种牙周修复用多孔纤维膜材料及其制备方法. 授权公告号：CN107320787 B
2. 王淑芳，Adam C. Midgley，张琳，孔德领. 一种防疤痕皮肤创伤修复用水凝胶及其制备方法. 授权公告号：CN113069531 B
3. 王淑芳，杨强，董云生，赵艳红，马信龙，李云洁，张琳. 缓释双生长因子的含钙化层骨软骨支架及其制备方法, 授权公告号：CN110101917 B.
